Drug Combination Details
| General Information of the Combination (ID: C04404) | |||||
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| Name | Vinblastine | + | Docetaxel + Tamoxifen | ||
| Click to Show/Hide the Each NP or Drug Information of This Combination | |||||
| Name | Vinblastine NP Info | Drug Info | |||
| Structure |
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| Name | Drug Info | ||||
| Structure |
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| Disease |
Lung cancer
[ICD-11: 2C25]
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Investigative | [1] | ||
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Breast cancer
[ICD-11: 2C60]
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Investigative | [1] | |||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| In-vitro Model | NCI-H1299 | CVCL_0060 | Lung large cell carcinoma | Homo sapiens | ||
| MDA-MB-231 | CVCL_0062 | Breast adenocarcinoma | Homo sapiens | |||
| Experimental
Result(s) |
Combination therapy of breast and lung cancer cell lines using docetaxel or vinblastine with tamoxifen synergistically increases the anti-proliferative affect of single agents. | |||||
| References | ||||
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| Reference 1 | Combination therapy increases the efficacy of docetaxel, vinblastine and tamoxifen in cancer cells. J Cancer Res Ther. Jul-Sep 2014;10(3):715-21. | |||
