Drug Combination Details
| General Information of the Combination (ID: C04501) | |||||
|---|---|---|---|---|---|
| Name | Theophylline NP Info | + | Methylprednisolone Drug Info | ||
| Structure |
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+ |
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| Disease |
Acute respiratory distress
[ICD-11: CB00]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| In-vivo Model | Male Wistar Albino rats were used in this study. | |||||
| Experimental
Result(s) |
Combined use of theophylline and methylprednisolone had positive effects on the contraction strength and the durations of contraction and semi-relaxation of the diaphragm muscle. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Effects of Theophylline with Methylprednisolone Combination Therapy on Biomechanics and Histopathology in Diaphragm Muscles of Rats. Inflammation. 2016 Oct;39(5):1635-41. | |||
