Drug Combination Details
| General Information of the Combination (ID: C08388) | |||||
|---|---|---|---|---|---|
| Name | Ferulic acid NP Info | + | 2-methoxyestradiol Drug Info | ||
| Structure |
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+ |
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| Disease |
Melanoma
[ICD-11: 2C30]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | HSPD1 | Molecule Info |
Pathway MAP
|
|
| In-vitro Model | A-375 | CVCL_0132 | Amelanotic melanoma | Homo sapiens | ||
| Experimental
Result(s) |
2-Methoxyestradiol and its combination with ferulic acid induces melanoma cell death via downregulation of Hsp60 and Hsp90. | |||||
