Drug Combination Details
| General Information of the Combination (ID: C08624) | |||||
|---|---|---|---|---|---|
| Name | Metformin NP Info | + | 5-fluorouracil Drug Info | ||
| Structure |
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+ |
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| Disease |
Colorectal cancer
[ICD-11: 2B91]
|
Phase 2 | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [2] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | TP53 | Molecule Info |
Pathway MAP
|
|
| In-vitro Model | C-26 | CVCL_XC68 | Colorectal cancer | Mus musculus | ||
| In-vivo Model | BALB/c mice inoculated with C26 cells were used in this study. | |||||
| Experimental
Result(s) |
The combination treatment of ME/5FU co-loaded hydrogels exhibited significant synergistic therapeutic efficacy in the BALB/c mouse model with transplanted subcutaneously tumor on the base of C26 cell line by inducing apoptosis and cell cycle arrest. | |||||
| Experiment 2 Reporting the Effect of This Combination | [3] | |||||
| In-vitro Model | HCT 116 | CVCL_0291 | Colon carcinoma | Homo sapiens | ||
| SW1463 | CVCL_1718 | Rectal adenocarcinoma | Homo sapiens | |||
| Experimental
Result(s) |
Metformin combined with 5-FU treatment significantly inhibited tumor cell proliferation and tumor metastasis. | |||||
