Drug Combination Details

General Information of the Combination (ID: C08897)
Name Tanshinone I   NP Info  + Lenalidomide   Drug Info 
Structure +
Disease
Multiple myeloma [ICD-11: 2A83]
Investigative [1]
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. Enhancing Drug Efficacy by This Combination
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Experiment 1 Reporting the Effect of This Combination [1]
                    Molecule(s)
                    Regulation		 Down-regulation Expression ACD  Molecule Info 
Pathway MAP
Down-regulation Expression TERF2IP  Molecule Info 
Pathway MAP
Down-regulation Expression TNKS-1  Molecule Info 
Pathway MAP
                    In-vitro Model RPMI-8226 CVCL_0014 Plasma cell myeloma Homo sapiens
U266B1 CVCL_0566 Plasma cell myeloma Homo sapiens
                    Experimental
                    Result(s)		 Combination of TanI with standard chemotherapeutic drug Len, potentiates cell death in myeloma cells.
References
Reference 1 Novel combination of tanshinone I and lenalidomide induces chemo-sensitivity in myeloma cells by modulating telomerase activity and expression of shelterin complex and its associated molecules. Mol Biol Rep. 2018 Dec;45(6):2429-2439.
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