Drug Combination Details
| General Information of the Combination (ID: C09974) | |||||
|---|---|---|---|---|---|
| Name | Fosfomycin NP Info | + | N-acetylcysteine Drug Info | ||
| Structure |
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+ |
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| Disease |
Cystitis
[ICD-11: GC00]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| In-vitro Model | Escherichia coli strains | Microorganism model | Escherichia coli | |||
| Experimental
Result(s) |
Fosfomycin and NAC at concentrations achievable in urine displayed a synergistic effect promoting both the formation of biofilms and reduction of sessile cell viability. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Effect of fosfomycin alone and in combination with N-acetylcysteine on E. coli biofilms. Int J Antimicrob Agents. 2003 Oct;22 Suppl 2:95-100. | |||
