Drug Combination Details
| General Information of the Combination (ID: C11954) | |||||
|---|---|---|---|---|---|
| Name | Mycophenolate mofetil NP Info | + | Mizoribine Drug Info | ||
| Structure |
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+ |
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| Disease |
Discovery agent
[ICD-11: N.A.]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| In-vitro Model | T-cell populations from B6 mice | Healthy | Rattus norvegicus | |||
| In-vivo Model | Heterotopic vascularized heart transplantation was performed into the right cervical portion of the B6 mice. | |||||
| Experimental
Result(s) |
The combination of MMF and MZ showed mild synergistic effects in the inhibition of MLR and strong synergistic effects in a mouse heart transplantation model. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Combination effect of mycophenolate mofetil with mizoribine on cell proliferation assays and in a mouse heart transplantation model. Transplantation. 2006 Jul 27;82(2):175-9. | |||
