Drug Combination Details
| General Information of the Combination (ID: C12386) | |||||
|---|---|---|---|---|---|
| Name | Arsenic trioxide NP Info | + | Dithiothreitol Drug Info | ||
| Structure |
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+ |
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| Disease |
Lip/oral cavity/pharynx neoplasm
[ICD-11: 2B6E]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| In-vivo Model | The co-treatment of the carcinogen 4-NQO (200 ug/ml) plus arecoline (500 ug/ml) in the drinking water for eight weeks to C57BL-6 mice specifically induced tongue cancer within a further 20 weeks. | |||||
| Experimental
Result(s) |
Arsenic trioxide plus dithiothreitol showed synergistic cytotoxic effects on mice oral cancer cells. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Synergistic cytotoxic effects of arsenic trioxide plus dithiothreitol on mice oral cancer cells. Anticancer Res. 2010 Sep;30(9):3655-60. | |||
