Drug Combination Details
| General Information of the Combination (ID: C14503) | |||||
|---|---|---|---|---|---|
| Name | Epinephrine NP Info | + | Esmolol Drug Info | ||
| Structure |
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+ |
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| Disease |
Cardiac Arrest
[ICD-11: MC82]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | TNNI3 | Molecule Info |
Pathway MAP
|
|
| Biological
Regulation |
Increase | 24-hour survival rate | ||||
| Down-regulation | Lactate level | |||||
| Up-regulation | Mean aortic pressure | |||||
| Up-regulation | Oxygen consumption | |||||
| Up-regulation | Oxygen delivery | |||||
| In-vivo Model | Twenty-four inbred Wuzhishan miniature pigs (12-14 months of age, 30+/-2 kg) were used in this study. | |||||
| Experimental
Result(s) |
Combination of epinephrine with esmolol attenuates post-resuscitation myocardial dysfunction in a porcine model of cardiac arrest. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Combination of epinephrine with esmolol attenuates post-resuscitation myocardial dysfunction in a porcine model of cardiac arrest. PLoS One. 2013 Dec 18;8(12):e82677. | |||
