Drug Combination Details
| General Information of the Combination (ID: C16480) | |||||
|---|---|---|---|---|---|
| Name | Cefixime NP Info | + | Ofloxacin Drug Info | ||
| Structure |
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+ |
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| Disease |
Typhoid fever
[ICD-11: 1A07]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| In-vitro Model | Salmonella Typhimurium | Microorganism model | Salmonella Typhimurium | |||
| Experimental
Result(s) |
Cefixime-ofloxacin combination could be effective against moderately susceptible fluoroquinolone S. Typhi but not fluoroquinolone-resistant isolates. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | In vitro efficacy and in silico analysis of cefixime-ofloxacin combination for Salmonella Typhi from bloodstream infection. J Appl Microbiol. 2017 Sep;123(3):615-624. | |||
