| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally |
| α. Enhancing Drug Efficacy by This Combination |
| Achieving Therapeutic Synergy |
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| Experiment 1 Reporting the Effect of This Combination |
[1] |
| In-vivo Model |
For a xenograft model: Male Sprague Dawley rats (120-140 g) were anaesthetized with isoflurane, and arthritis was induced in the left knee by an intrarticular injection of 2 mg MIA in 25 ul of 0.9% saline. |
Experimental
Result(s) |
The combination therapy of tapentadol and pregabalin restored descending noradrenergic inhibitory tone and also inhibited nociceptive transmission at the level of the spinal cord can provide superior analgesia. |
