| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally |
| α. Enhancing Drug Efficacy by This Combination |
| Achieving Therapeutic Synergy |
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| Experiment 1 Reporting the Effect of This Combination |
[1] |
| In-vitro Model |
Enterococcus faecium ATCC 19434 |
Microorganism model |
Enterococcus faecium |
| Staphylococcus aureus ATCC 25923 |
Microorganism model |
Staphylococcus aureus |
| Streptococcus mutans ATCC 3065 |
Microorganism model |
Streptococcus mutans |
| Escherichia coli ATCC 43895 |
Microorganism model |
Escherichia coli |
| Escherichia coli ATCC 25922 |
Microorganism model |
Escherichia coli |
| Pseudomonas aeruginosa ATCC 27853 |
Microorganism model |
Pseudomonas aeruginosa |
Experimental
Result(s) |
Amentoflavone had a considerable antibacterial effect and synergistic interaction with antibiotics against various bacterial strains. The formation of hydroxyl radical would be a cause of the synergistic effect and that this oxidative stress originated from a transient NADH depletion. . |
