Drug Combination Details
| General Information of the Combination (ID: C17908) | |||||
|---|---|---|---|---|---|
| Name | Phenethyl isothiocyanate NP Info | + | Cisplatin Drug Info | ||
| Structure |
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+ |
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| Disease |
Pleural mesothelioma
[ICD-11: 2C26]
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Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Biological
Regulation |
Up-regulation | ROS generation | ||||
| In-vitro Model | Meso4 | CVCL_H678 | Pleural epithelioid mesothelioma | Homo sapiens | ||
| Meso11 | CVCL_H670 | Pleural epithelioid mesothelioma | Homo sapiens | |||
| Meso13 | CVCL_H672 | Pleural epithelioid mesothelioma | Homo sapiens | |||
| Meso34 | CVCL_H675 | Pleural epithelioid mesothelioma | Homo sapiens | |||
| Meso47 | CVCL_H680 | Pleural epithelioid mesothelioma | Homo sapiens | |||
| Meso56 | CVCL_H681 | Pleural epithelioid mesothelioma | Homo sapiens | |||
| Meso96 | CVCL_H683 | Pleural epithelioid mesothelioma | Homo sapiens | |||
| Meso76 cells established from pleural fluids of patients | Malignant Pleural Mesothelioma | Homo sapiens | ||||
| Meso152 cells established from pleural fluids of patients | Malignant pleural mesothelioma | Homo sapiens | ||||
| Experimental
Result(s) |
The combination of cisplatin with the natural compound PEITC induces a strong MPM cell death, while remaining safe for PMC, with limited emergence of cell resistance compared to drugs used alone. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Cisplatin in combination with Phenethyl Isothiocyanate (PEITC), a potential new therapeutic strategy for malignant pleural mesothelioma. Oncotarget. 2014 Nov 30;5(22):11641-52. | |||
