Drug Combination Details
| General Information of the Combination (ID: C19026) | |||||
|---|---|---|---|---|---|
| Name | Selenium NP Info | + | Sulfamethoxazole Drug Info | ||
| Structure |
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+ |
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| Disease |
Hepatocellular carcinoma
[ICD-11: 2C12]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| In-vivo Model | This experiment was carried out on 30 Wistar rats weighing 100-125 g, liver cancer was induced by a carcinogenic dose of 200 mg/kg body weight, I.P. DENA when associated with fasting/refeeding. | |||||
| Experimental
Result(s) |
Selenium and sulfonamide (sulfamethoxazole) together can possess synergistic chemopreventive action. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Combination of sulfamethoxazole and selenium in anticancer therapy: a novel approach. Mol Cell Biochem. 2013 Dec;384(1-2):279-85. | |||
