Drug Combination Details
| General Information of the Combination (ID: C19445) | |||||
|---|---|---|---|---|---|
| Name | Citicoline NP Info | + | Hypothermia Drug Info | ||
| Structure |
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+ |
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| Disease |
Ischemic stroke
[ICD-11: 8B11]
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Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| In-vivo Model | Middle cerebral artery occlusion (MCAo) was performed for 2 hours on Sprague-Dawley (SD) rats using intraluminal thread insertion. | |||||
| Experimental
Result(s) |
By suppressing apoptotic processes citicoline with hypothermia is more effective than either used alone in ameliorating cerebral damage after transient focal ischemia. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Effects of citicoline used alone and in combination with mild hypothermia on apoptosis induced by focal cerebral ischemia in rats. J Clin Neurosci. 2010 Feb;17(2):227-31. | |||
