Drug Combination Details

General Information of the Combination (ID: C20892)
Name Metformin   NP Info  + Atorvastatin   Drug Info 
Structure +
Disease
Type 2 diabetes mellitus [ICD-11: 5A11]
Phase 3 [1]
Gastrointestinal stromal tumor [ICD-11: 2B5B]
Investigative [2]
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. Enhancing Drug Efficacy by This Combination
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Experiment 1 Reporting the Effect of This Combination [2]
                    In-vivo Model Clinical trial
                    Experimental
                    Result(s)		 Use of statin and metformin provides a synergistic improvement in gastrointestinal malignancies outcomes.
References
Reference 1 ClinicalTrials.gov (NCT02947620) A Multi-center, Randomized, Double-blind, Active-controlled, Phase 3 Clinical Trial to Evaluate the Safety and Efficacy of Metformin/Atorvastatin Combination Therapy in Subjects With Type II Diabetes and Dyslipidemia.
Reference 2 Synergistic Benefit of Statin and Metformin in Gastrointestinal Malignancies. J Pharm Pract. 2017 Apr;30(2):185-194.
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