Drug Combination Details
| General Information of the Combination (ID: C22796) | |||||
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| Name | Alpha solanine | + | 5-fluorouracil + Cisplatin | ||
| Click to Show/Hide the Each NP or Drug Information of This Combination | |||||
| Name | Alpha solanine NP Info | Drug Info | |||
| Structure |
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| Name | Drug Info | ||||
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| Disease |
Esophageal cancer
[ICD-11: 2B70]
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Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
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| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | BIRC5 | Molecule Info |
Pathway MAP
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| In-vitro Model | EC9706 | CVCL_E307 | Esophageal squamous cell carcinoma | Homo sapiens | ||
| KYSE-30 | CVCL_1351 | Esophageal squamous cell carcinoma | Homo sapiens | |||
| In-vivo Model | EC9706 cells (5*106), which were labeled with firefly luciferase, were subcutaneously inoculated into the armpit of the right forelimb of 6-week-old female BALB/c nude mice. | |||||
| Experimental
Result(s) |
Alpha-solanine enhances the chemosensitivity of esophageal cancer cells by inducing microRNA 138 expression. | |||||
| References | ||||
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| Reference 1 | Alpha-solanine enhances the chemosensitivity of esophageal cancer cells by inducing microRNA?138 expression. Oncol Rep. 2018 Mar;39(3):1163-1172. | |||
