Drug Combination Details
| General Information of the Combination (ID: C23300) | |||||
|---|---|---|---|---|---|
| Name | Quercetin NP Info | + | Dacarbazine Drug Info | ||
| Structure |
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| Disease |
Melanoma
[ICD-11: 2C30]
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Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Biological
Regulation |
Increase | Nuclear localization of deltaNp73 | ||||
| In-vitro Model | DB1 | CVCL_W884 | Diffuse large B-cell lymphoma | Homo sapiens | ||
| SK-MEL-28 | CVCL_0526 | Cutaneous melanoma | Homo sapiens | |||
| Experimental
Result(s) |
Quercetin abrogates chemoresistance in melanoma cells by modulating deltaNp73. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Quercetin abrogates chemoresistance in melanoma cells by modulating deltaNp73. BMC Cancer. 2010 Jun 11;10:282. | |||
