Drug Combination Details
| General Information of the Combination (ID: C27255) | |||||
|---|---|---|---|---|---|
| Name | Vinblastine NP Info | + | Temsirolimus Drug Info | ||
| Structure |
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+ |
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| Disease |
Lymphoma
[ICD-11: 2A80-2A86]
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Phase 1 | [1] | ||
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Hepatocellular carcinoma
[ICD-11: 2C12]
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Investigative | [2] | |||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [2] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | EIF4EBP1 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | mTOR | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | S6K1 | Molecule Info |
Pathway MAP
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| In-vitro Model | Hep 3B2.1-7 | CVCL_0326 | Childhood hepatocellular carcinoma | Homo sapiens | ||
| Hep-G2 | CVCL_0027 | Hepatocellular carcinoma | Homo sapiens | |||
| PLC/PRF/5 | CVCL_0485 | Adult hepatocellular carcinoma | Homo sapiens | |||
| SNU-398 | CVCL_0077 | Adult hepatocellular carcinoma | Homo sapiens | |||
| In-vivo Model | HCC cells (2 * 106 of Huh7 cells or 3 * 106 of Hep3B cells suspended in 200 ul serum free medium) were inoculated into the dorsal flanks of male athymic nude mice (nu/nu) by subcutaneous injection. | |||||
| Experimental
Result(s) |
The potent anti-cancer activity of this co-targeting strategy was indeed mediated in parts by inhibition of these key survival/anti-apoptotic proteins. | |||||
