Drug Combination Details
| General Information of the Combination (ID: C30347) | |||||
|---|---|---|---|---|---|
| Name | Asiaticoside NP Info | + | Rapamycin Drug Info | ||
| Structure |
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+ |
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| Disease |
Discovery agent
[ICD-11: N.A.]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | TGFB1 | Molecule Info | ||
| In-vitro Model | Human aortic smooth muscle cell | Healthy | Homo sapiens | |||
| Human aortic fibroblasts | Healthy | Homo sapiens | ||||
| Human coronary artery endothelial cells | Healthy | Homo sapiens | ||||
| Experimental
Result(s) |
Asiaticoside combined with rapamycin may be effective in the reduction of ISR. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Combination treatment with asiaticoside and rapamycin: A new hope for in-stent restenosis. Exp Ther Med. 2013 Aug;6(2):557-561. | |||
