Drug Combination Details
| General Information of the Combination (ID: C30890) | |||||
|---|---|---|---|---|---|
| Name | Calcitonin NP Info | + | Prednisolone Drug Info | ||
| Structure |
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+ |
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| Disease |
Rheumatoid arthritis
[ICD-11: FA20]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | ODF | Molecule Info |
Pathway MAP
|
|
| In-vitro Model | U2OS | CVCL_0042 | Osteosarcoma | Homo sapiens | ||
| SaOS-2 | CVCL_0548 | Osteosarcoma | Homo sapiens | |||
| T-47D | CVCL_0553 | Invasive breast carcinoma | Homo sapiens | |||
| In-vivo Model | CIA. Female Lewis rats (150 +/- 20 g body weight) were used in this study. | |||||
| Experimental
Result(s) |
Calcitonin and Prednisolone display antagonistic actions on bone and have synergistic effects in experimental Arthritis. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Calcitonin and prednisolone display antagonistic actions on bone and have synergistic effects in experimental arthritis. Am J Pathol. 2007 Mar;170(3):1018-27. | |||
