Drug Combination Details
| General Information of the Combination (ID: C31047) | |||||
|---|---|---|---|---|---|
| Name | Cucurbitacin E NP Info | + | 5-fluorouracil Drug Info | ||
| Structure |
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+ |
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| Disease |
Colorectal cancer
[ICD-11: 2B91]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | ABCC1 | Molecule Info |
Pathway MAP
|
|
| In-vitro Model | DLD-1 | CVCL_0248 | Colon adenocarcinoma | Homo sapiens | ||
| HCT 8 | CVCL_2478 | Colon adenocarcinoma | Homo sapiens | |||
| HCT 116 | CVCL_0291 | Colon carcinoma | Homo sapiens | |||
| FHC | CVCL_3688 | Healthy | Homo sapiens | |||
| In-vivo Model | Six-week-old female nude mice received a subcutaneous injection of HCT-8/FU cells (1 * 106 suspended in 100 uL of PBS) on the right flank. | |||||
| Experimental
Result(s) |
Cucurbitacin E chemosensitizes colorectal cancer cells via mitigating TFAP4/Wnt/Beta-Catenin signaling. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Cucurbitacin E Chemosensitizes Colorectal Cancer Cells via Mitigating TFAP4/Wnt/Beta-Catenin Signaling. J Agric Food Chem. 2020 Nov 18. | |||
