Drug Combination Details
| General Information of the Combination (ID: C35524) | |||||
|---|---|---|---|---|---|
| Name | Arsenic trioxide NP Info | + | Docosahexaenoic acid Drug Info | ||
| Structure |
|
+ |
|
||
| Disease |
Acute myeloid leukemia
[ICD-11: 2A60]
|
Investigative | [1] | ||
|
Colon cancer
[ICD-11: 2B90]
|
Investigative | [2] | |||
|
Pancreatic cancer
[ICD-11: 2C10]
|
Investigative | [2] | |||
|
Breast cancer
[ICD-11: 2C60]
|
Investigative | [2] | |||
|
Ovarian cancer
[ICD-11: 2C73]
|
Investigative | [2] | |||
|
Cervical cancer
[ICD-11: 2C77]
|
Investigative | [2] | |||
|
Prostate cancer
[ICD-11: 2C82]
|
Investigative | [2] | |||
| Click to Show/Hide the Whole Disease Information of This Combination | |||||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Up-regulation | Cleavage | CASP3 | Molecule Info |
Pathway MAP
|
|
| In-vitro Model | HL-60 | CVCL_0002 | Adult acute myeloid leukemia | Homo sapiens | ||
| Experimental
Result(s) |
Docosahexaenoic acid enhances arsenic trioxide-mediated apoptosis in arsenic trioxide-resistant HL-60 cells. | |||||
| Experiment 2 Reporting the Effect of This Combination | [2] | |||||
| In-vitro Model | HT-29 | CVCL_0320 | Colon adenocarcinoma | Homo sapiens | ||
| SW620 | CVCL_0547 | Colon adenocarcinoma | Homo sapiens | |||
| LS174T | CVCL_1384 | Colon adenocarcinoma | Homo sapiens | |||
| PANC-1 | CVCL_0480 | Pancreatic ductal adenocarcinoma | Homo sapiens | |||
| MDA-MB-468 | CVCL_0419 | Breast adenocarcinoma | Homo sapiens | |||
| SK-BR-3 | CVCL_0033 | Breast adenocarcinoma | Homo sapiens | |||
| MCF-7 | CVCL_0031 | Invasive breast carcinoma | Homo sapiens | |||
| ES-2 | CVCL_3509 | Ovarian clear cell adenocarcinoma | Homo sapiens | |||
| SK-OV-3 | CVCL_0532 | Ovarian serous cystadenocarcinoma | Homo sapiens | |||
| HeLa | CVCL_0030 | Endocervical adenocarcinoma | Homo sapiens | |||
| PC-3 | CVCL_0035 | Prostate carcinoma | Homo sapiens | |||
| Experimental
Result(s) |
Docosahexaenoic acid enhances arsenic trioxide-mediated apoptosis in arsenic trioxide-resistant solid tumor cells. | |||||
