Drug Combination Details

General Information of the Combination (ID: C36127)
Name Estramustine   NP Info  + Docetaxel   Drug Info 
Structure +
Disease
Prostate cancer [ICD-11: 2C82]
Phase 2 [1]
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. Enhancing Drug Efficacy by This Combination
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Experiment 1 Reporting the Effect of This Combination [2]
                    In-vitro Model PC-3 CVCL_0035 Prostate carcinoma Homo sapiens
LNCaP CVCL_0395 Prostate carcinoma Homo sapiens
                    Experimental
                    Result(s)		 These results provide novel molecular targets of docetaxel and estramustine combination treatment in prostate cancer cells.
References
Reference 1 ClinicalTrials.gov (NCT00193271) Adjuvant Docetaxel and Estramustine Phosphate for High Risk Localized Prostate Cancer.
Reference 2 Gene expression profiling revealed novel molecular targets of docetaxel and estramustine combination treatment in prostate cancer cells. Mol Cancer Ther. 2005 Mar;4(3):389-98.
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