Drug Combination Details

General Information of the Combination (ID: C37217)
Name Vancomycin   NP Info  + Cisplatin   Drug Info 
Structure +
Disease
Healthy individual [ICD-11: N.A.]
Investigative [1]
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. Decreasing Adverse Drug Reaction by This Combination
                 Decreasing Adverse Drug Reaction     Click to Show/Hide
                    Experiment 1 Reporting the Effect of This Combination [1]
                    Biological
                    Regulation		 Reduction Cisplatin-induced lipid peroxidation
                    In-vivo Model Healthy adult male albino rats (8-10 weeks old; weighing 120-180 g) of Wistar strain were used in this study.
                    Experimental
                    Result(s)		 Vanillic acid is a potential antioxidant that reduce cisplatin nephrotoxicity and can be as a combinatorial regimen in cancer chemotherapy.
References
Reference 1 Nephroprotective effect of vanillic acid against cisplatin induced nephrotoxicity in wistar rats: a biochemical and molecular study. Environ Toxicol Pharmacol. 2015 Jan;39(1):392-404.
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