Drug Combination Details
| General Information of the Combination (ID: C37534) | |||||
|---|---|---|---|---|---|
| Name | Wogonin NP Info | + | Oxaliplatin Drug Info | ||
| Structure |
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+ |
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| Disease |
Stomach cancer
[ICD-11: 2B72]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Augmenting Drug Sensitivity | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Up-regulation | Phosphorylation | JNK1 | Molecule Info |
Pathway MAP
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| Down-regulation | Phosphorylation | ULK1 | Molecule Info |
Pathway MAP
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| Biological
Regulation |
Up-regulation | Peroxynitrite formation | ||||
| In-vitro Model | BGC-823 | CVCL_3360 | Gastric cancer | Homo sapiens | ||
| In-vivo Model | Approximately 300 cells for the CM-Dil-labeled BGC-823 cells were injected into the yolk sac per zebrafish embryo using a microinjector. | |||||
| Experimental
Result(s) |
Wogonin exacerbates the cytotoxic effect of oxaliplatin by inducing nitrosative stress and autophagy in human gastric cancer cells. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Wogonin exacerbates the cytotoxic effect of oxaliplatin by inducing nitrosative stress and autophagy in human gastric cancer cells. Phytomedicine. 2018 Jan 15;39:168-175. | |||
