Drug Combination Details

General Information of the Combination (ID: C40150)
Name Beta caryophyllene   NP Info  + Imipramine   Drug Info 
Structure +
Disease
Multiple sclerosis [ICD-11: 8A40]
Investigative [1]
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. Enhancing Drug Efficacy by This Combination
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Experiment 1 Reporting the Effect of This Combination [1]
                    In-vivo Model To establish experimental autoimmune encephalomyelitis (EAE) mice, female C57BL/6 mice were actively immunized using two subcutaneous injections with an emulsion containing myelin MOG35-55 (250 g) and an equal volume of CFA (250 g) into dierent sites of each hind ank.
                    Experimental
                    Result(s)		 They reduced the clinical and pathological defects in EAE mice through modulation of both local (microglia) and systemic (lymphocytes and blood) immunity from inflammatory (Th1/Th17/M1) towards anti-inflammatory (Th2/Treg/M2) phenotypes.
References
Reference 1 Combination of Imipramine, a sphingomyelinase inhibitor, and Beta-caryophyllene improve their therapeutic effects on experimental autoimmune encephalomyelitis (EAE). Int Immunopharmacol. 2019 Dec;77:105923.
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