Drug Combination Details

General Information of the Combination (ID: C40967)
Name Fosfomycin   NP Info  + Meropenem   Drug Info 
Structure +
Disease
Pneumonia [ICD-11: CA40]
Investigative [1]
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. Enhancing Drug Efficacy by This Combination
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Experiment 1 Reporting the Effect of This Combination [2]
                    In-vitro Model Pseudomonas aeruginosa PAO1 Microorganism model Pseudomonas aeruginosa
                    Experimental
                    Result(s)		 The combination of fosfomycin plus meropenem is synergistic for pseudomonas aeruginosa PAO1 in a hollow-fiber infection model.
    β. Reversing Drug Resistance by This Combination
                 Reversing Drug Resistance     Click to Show/Hide
                    Experiment 1 Reporting the Effect of This Combination [1]
                    In-vitro Model Pseudomonas aeruginosa isolates Microorganism model Pseudomonas aeruginosa
                    Experimental
                    Result(s)		 The increase in pharmacodynamic activities resulting from the synergistic action of meropenem with fosfomycin demonstrates the potential relevance of this combination to fight infections caused by MDR and MBL-producing P. aeruginosa strains.
References
Reference 1 Pharmacodynamic Attainment of the Synergism of Meropenem and Fosfomycin Combination against Pseudomonas aeruginosa Producing Metallo-Beta-Lactamase. Antimicrob Agents Chemother. 2019 May 24;63(6):e00126-19.
Reference 2 The Combination of Fosfomycin plus Meropenem Is Synergistic for Pseudomonas aeruginosa PAO1 in a Hollow-Fiber Infection Model. Antimicrob Agents Chemother. 2018 Nov 26;62(12):e01682-18.
 Download Picture         KEGG Link