Drug Combination Details
| General Information of the Combination (ID: C44388) | |||||
|---|---|---|---|---|---|
| Name | Deguelin NP Info | + | Cisplatin Drug Info | ||
| Structure |
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+ |
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| Disease |
Stomach cancer
[ICD-11: 2B72]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | BRCA1 | Molecule Info |
Pathway MAP
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| In-vitro Model | MGC-803 | CVCL_5334 | Gastric mucinous adenocarcinoma | Homo sapiens | ||
| Experimental
Result(s) |
The combined treatment of deguelin and cisplatin exhibited a marked inhibition of MGC-803 cell proliferation when compared with that of the single therapies in vitro. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Synergistic antitumor effects of combined deguelin and cisplatin treatment in gastric cancer cells. Oncol Lett. 2014 Oct;8(4):1603-1607. | |||
