Drug Combination Details
| General Information of the Combination (ID: C45375) | |||||
|---|---|---|---|---|---|
| Name | Genistein NP Info | + | 1,3-bis(2-chloroethyl)-1-nitrosourea Drug Info | ||
| Structure |
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+ |
|
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| Disease |
Brain cancer
[ICD-11: 2A00]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| In-vitro Model | U-87MG ATCC | CVCL_0022 | Glioblastoma | Homo sapiens | ||
| Experimental
Result(s) |
Genistein at typical adult dietary plasma levels can significantly enhance the antiproliferative and cytotoxic action of BCNU. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Synergistic effect of genistein and BCNU on growth inhibition and cytotoxicity of glioblastoma cells. J Neurooncol. 2002 May;57(3):193-200. | |||
