Drug Combination Details
| General Information of the Combination (ID: C45595) | |||||
|---|---|---|---|---|---|
| Name | Quercetin NP Info | + | Chloroquine Drug Info | ||
| Structure |
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+ |
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| Disease |
Brain cancer
[ICD-11: 2A00]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Biological
Regulation |
Induction | Ca(2+) homeostasis disruption | ||||
| Induction | Lysosomal defects | |||||
| In-vitro Model | T98G | CVCL_0556 | Glioblastoma | Homo sapiens | ||
| U-251MG | CVCL_0021 | Astrocytoma | Homo sapiens | |||
| U-373MG ATCC | CVCL_2219 | Astrocytoma | Homo sapiens | |||
| Experimental
Result(s) |
Quercetin and chloroquine synergistically kill glioma cells by inducing organelle stress and disrupting Ca2+ homeostasis. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Quercetin and chloroquine synergistically kill glioma cells by inducing organelle stress and disrupting Ca 2+ homeostasis. Biochem Pharmacol. 2020 Aug;178:114098. | |||
