Drug Combination Details
| General Information of the Combination (ID: C47222) | |||||
|---|---|---|---|---|---|
| Name | Streptozocin NP Info | + | 5-fluorouracil Drug Info | ||
| Structure |
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+ |
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| Disease |
Pancreatic cancer
[ICD-11: 2C10]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| In-vivo Model | Medical records | |||||
| Experimental
Result(s) |
The combination of STZ and 5-FU is effective in the treatment of pNETs in terms of survival and radiological response and has an acceptable toxicity profile. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Streptozocin and 5-Fluorouracil for the Treatment of Pancreatic Neuroendocrine Tumors: Efficacy, Prognostic Factors and Toxicity. Neuroendocrinology. 2016;103(3-4):345-53. | |||
