Drug Combination Details
| General Information of the Combination (ID: C47754) | |||||
|---|---|---|---|---|---|
| Name | Tretinoin NP Info | + | Atorvastatin Drug Info | ||
| Structure |
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+ |
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| Disease |
Multiple sclerosis
[ICD-11: 8A40]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | CDH2 | Molecule Info |
Pathway MAP
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| In-vivo Model | MOG35-55 in female C57BL/6 mice were used in this study. | |||||
| Experimental
Result(s) |
Combined atorvastatin and ATRA have immunomodulatory synergistic benefits. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Synergistic effects of atorvastatin and all-trans retinoic acid in ameliorating animal model of multiple sclerosis. Immunol Invest. 2014;43(1):54-68. | |||
