Drug Combination Details

General Information of the Combination (ID: C48038)
Name Naringin   NP Info  + Trimetazidine   Drug Info 
Structure +
Disease
Renal failure [ICD-11: GB60]
Investigative [1]
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. Enhancing Drug Efficacy by This Combination
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Experiment 1 Reporting the Effect of This Combination [1]
                    In-vivo Model Forty male Sprague-Dawley rats weighting ranged from 200 to 250 g were used in this study.
                    Experimental
                    Result(s)		 NAR, TMZ, or their combination could attenuate the Nrf-2 expression in the kidney tissue, following the renal IR injury through inhibition of lipid peroxidase, and enhancement of antioxidant activity.
References
Reference 1 Protective effects of naringin and trimetazidine on remote effect of acute renal injury on oxidative stress and myocardial injury through Nrf-2 regulation. Pharmacol Rep. 2019 Dec;71(6):1059-1066.
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