Drug Combination Details
| General Information of the Combination (ID: C48418) | |||||
|---|---|---|---|---|---|
| Name | Dicoumarol NP Info | + | Oxaliplatin Drug Info | ||
| Structure |
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+ |
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| Disease |
Hepatocellular carcinoma
[ICD-11: 2C12]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Reversing Drug Resistance by This Combination | ||||||
| Reversing Drug Resistance | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | CYB5R2 | Molecule Info |
Pathway MAP
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| In-vitro Model | SNU-449 | CVCL_0454 | Adult hepatocellular carcinoma | Homo sapiens | ||
| SNU-387 | CVCL_0250 | Adult hepatocellular carcinoma | Homo sapiens | |||
| Experimental
Result(s) |
Dicoumarol enhances gemcitabine-induced cytotoxicity in high NQO1-expressing cholangiocarcinoma cells. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Dicoumarol enhances gemcitabine-induced cytotoxicity in high NQO1-expressing cholangiocarcinoma cells. World J Gastroenterol. 2010 May 21;16(19):2362-70. | |||
