Drug Combination Details

General Information of the Combination (ID: C49909)
Name L-canavanine   NP Info  + 5-fluorouracil   Drug Info 
Structure +
Disease
Pancreatic cancer [ICD-11: 2C10]
Investigative [1]
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. Enhancing Drug Efficacy by This Combination
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Experiment 1 Reporting the Effect of This Combination [1]
                    In-vitro Model MIA PaCa-2 CVCL_0428 Pancreatic ductal adenocarcinoma Homo sapiens
                    In-vivo Model Male Fishcher rats weighing 150-175 g were used in this study.
                    Experimental
                    Result(s)		 Combination therapy offers a viable means of improving L-canavanine's intrinsic efficacy while decreasing the concentration of 5-FU required to produce the same cytotoxic effect.
References
Reference 1 Combination therapy with 5-fluorouracil and L-canavanine: in vitro and in vivo studies. Anticancer Drugs. 1995 Aug;6(4):586-93.
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