Drug Combination Details

General Information of the Combination (ID: C51793)
Name Mycophenolate mofetil   NP Info  + Everolimus   Drug Info 
Structure +
Disease
Cytomegalovirus infection [ICD-11: 1A24]
Phase 4 [1]
Discovery agent [ICD-11: N.A.]
Investigative [2]
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. Decreasing Adverse Drug Reaction by This Combination
                 Decreasing Adverse Drug Reaction     Click to Show/Hide
                    Experiment 1 Reporting the Effect of This Combination [2]
                    In-vivo Model Clinical Trial
                    Experimental
                    Result(s)		 This regimen was proven to be efficient to prevent and treat nephrotoxicity and neurotoxicity with an acceptable tolerability profile.
References
Reference 1 ClinicalTrials.gov (NCT02328963) Proportion of CMV Seropositive Kidney Transplant Recipients Who Will Develop a CMV Infection When Treated With an Immunosuppressive Regimen Including Everolimus and Reduced Dose of Cyclosporine Versus an Immunosuppressive Regimen With Mycophenolic Acid and Standard Dose of Cyclosporine A (EVERCMV).
Reference 2 Everolimus plus mycophenolate mofetil as initial immunosuppression in liver transplantation. Transplant Proc. Jan-Feb 2015;47(1):90-2.
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