Drug Combination Details
| General Information of the Combination (ID: C52797) | |||||
|---|---|---|---|---|---|
| Name | Sinomenine NP Info | + | Methotrexate Drug Info | ||
| Structure |
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+ |
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| Disease |
Rheumatoid arthritis
[ICD-11: FA20]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | IL6 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | MMP-9 | Molecule Info |
Pathway MAP
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| In-vivo Model | Arthritis was induced by immunizing with CII in female Srague-Dawley rats. | |||||
| Experimental
Result(s) |
SIN and MTX have additive effects, decreasing inflammation and joint damage in CIA rats by modulating osteoclast-related cytokines. These results are indicative of the combined effect of SIN and MTX for anti-arthritic treatment in RA. | |||||
