Drug Combination Details
| General Information of the Combination (ID: C52845) | |||||
|---|---|---|---|---|---|
| Name | Pterostilbene NP Info | + | Tamoxifen Drug Info | ||
| Structure |
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+ |
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| Disease |
Breast cancer
[ICD-11: 2C60]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| In-vitro Model | MCF-7 | CVCL_0031 | Invasive breast carcinoma | Homo sapiens | ||
| ZR-75-1 | CVCL_0588 | Invasive breast carcinoma | Homo sapiens | |||
| Experimental
Result(s) |
Pterostilbene shows an additive inhibitory effect on breast cancer cells when combined with tamoxifen, most likely from augmented cancer cell apoptosis. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Pterostilbene and tamoxifen show an additive effect against breast cancer in vitro. Am J Surg. 2010 Nov;200(5):577-80. | |||
