Drug Combination Details
| General Information of the Combination (ID: C52865) | |||||
|---|---|---|---|---|---|
| Name | Iloprost NP Info | + | Montelukast Drug Info | ||
| Structure |
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+ |
|
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| Disease |
Spinal cord ischemia
[ICD-11: 8B42]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | IL6 | Molecule Info |
Pathway MAP
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| Experimental
Result(s) |
Combined use of iloprost and montelukast may reduce ischemic damage in transient spinal cord ischemia and may provide better neurological outcome. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Efficacy of iloprost and montelukast combination on spinal cord ischemia/reperfusion injury in a rat model. J Cardiothorac Surg. 2013 Apr 4;8:64. | |||
