Drug Combination Details

General Information of the Combination (ID: C52995)
Name Anidulafungin   NP Info  + Voriconazole   Drug Info 
Structure +
Disease
Aspergillosis [ICD-11: 1F20]
Phase 3 [1]
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. Enhancing Drug Efficacy by This Combination
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Experiment 1 Reporting the Effect of This Combination [2]
                    Molecule(s)
                    Regulation		 Up-regulation Expression CYP51A1  Molecule Info 
Pathway MAP
                    In-vitro Model Aspergillus fumigatus Microorganism model Aspergillus fumigatus
                    Experimental
                    Result(s)		 The combination demonstrated synergy against the VCZ-R clinical isolate as well.
References
Reference 1 ClinicalTrials.gov (NCT00531479) Anidulafungin Plus Voriconazole Versus Voriconazole For The Treatment Of Invasive Aspergillosis.
Reference 2 In vitro efficacy of the combination of voriconazole and anidulafungin against voriconazole-resistant cyp51A mutants of Aspergillus fumigatus. Diagn Microbiol Infect Dis. 2012 Jun;73(2):135-7.
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