Drug Combination Details
| General Information of the Combination (ID: C53990) | |||||
|---|---|---|---|---|---|
| Name | Vitamin E NP Info | + | FTY720 Drug Info | ||
| Structure |
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+ |
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| Disease |
Ischemic stroke
[ICD-11: 8B11]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Up-regulation | Expression | HMOX1 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | SOD Cu-Zn | Molecule Info |
Pathway MAP
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| In-vivo Model | Sprague-Dawley rats were used in this study. | |||||
| Experimental
Result(s) |
Pre treatment with FTY720 combined with vitamin E exerts synergistic neuroprotective effects in the simulated cerebral ischemia in vitro. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Synergistic protective effect of FTY720 and vitamin E against simulated cerebral ischemia in vitro. Mol Med Rep. 2017 Jul;16(1):396-402. | |||
