Drug Combination Details
| General Information of the Combination (ID: C54961) | |||||
|---|---|---|---|---|---|
| Name | Betulin NP Info | + | Acyclovir Drug Info | ||
| Structure |
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+ |
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| Disease |
Herpes simplex viruses infection
[ICD-11: 1A94]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| In-vitro Model | Vero | CVCL_0059 | Healthy | Chlorocebus sabaeus | ||
| Experimental
Result(s) |
Strong and moderate synergistic antiviral effects were observed for betulin and ACV against HSV-1 when the concentrations of ACV and betulin were higher than 0.068 and 0.4 microg/ml, respectively. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | The synergistic effects of betulin with acyclovir against herpes simplex viruses. Antiviral Res. 2004 Nov;64(2):127-30. | |||
