Drug Combination Details

General Information of the Combination (ID: C55168)
Name Olanzapine   NP Info  + Fluoxetine   Drug Info 
Structure +
Disease
Depression [ICD-11: 6A70-6A71]
Phase 3 [1]
Bipolar disorder [ICD-11: 6A60]
Investigative [2]
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. Enhancing Drug Efficacy by This Combination
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Experiment 1 Reporting the Effect of This Combination [2]
                    In-vivo Model Clinical Trial
                    Experimental
                    Result(s)		 Olanzapine/fluoxetine combination demonstrated rapid onset of antidepressant effect (within 7 days) compared to placebo that was sustained over 8 weeks of treatment in a sample of BD patients.
References
Reference 1 ClinicalTrials.gov (NCT00035321) The Study of Olanzapine Plus Fluoxetine in Combination for Treatment of Treatment Resistant Depression.
Reference 2 Onset of antidepressant effect of olanzapine and olanzapine/fluoxetine combination in bipolar depression. Bipolar Disord. 2007 Sep;9(6):618-27.
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