Drug Combination Details
| General Information of the Combination (ID: C55582) | |||||
|---|---|---|---|---|---|
| Name | Withaferin A NP Info | + | Caffeic acid phenethyl ester Drug Info | ||
| Structure |
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+ |
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| Disease |
Ovarian cancer
[ICD-11: 2C73]
|
Investigative | [1] | ||
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Cervical cancer
[ICD-11: 2C77]
|
Investigative | [1] | |||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | TP53 | Molecule Info |
Pathway MAP
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| In-vitro Model | SK-OV-3 | CVCL_0532 | Ovarian serous cystadenocarcinoma | Homo sapiens | ||
| OVK18 | CVCL_3770 | Ovarian endometrioid adenocarcinoma | Homo sapiens | |||
| HeLa | CVCL_0030 | Endocervical adenocarcinoma | Homo sapiens | |||
| SKG-II | CVCL_2794 | Cervical squamous cell carcinoma | Homo sapiens | |||
| SKG-IIIb | CVCL_2795 | Cervical squamous cell carcinoma | Homo sapiens | |||
| ME-180 | CVCL_1401 | Cervical squamous cell carcinoma | Homo sapiens | |||
| In-vivo Model | Effect of Wi-A, CAPE and their combination was examined by female 4-5 weeks old BALB/c nude mice in vivo tumor growth assay using subcutaneous xenografts of SKOV-3. | |||||
| Experimental
Result(s) |
A combination of Wi-A and CAPE offers selective toxicity and better potency to cancer cells. | |||||
