Drug Combination Details

General Information of the Combination (ID: C57472)
Name Melatonin   NP Info  + Cisplatin   Drug Info 
Structure +
Disease
Atrophic vaginitis [ICD-11: GA30]
Investigative [1]
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. Enhancing Drug Efficacy by This Combination
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Experiment 1 Reporting the Effect of This Combination [1]
                    Molecule(s)
                    Regulation		 Up-regulation Expression TP53  Molecule Info 
Pathway MAP
                    In-vivo Model Four-week-old female CD-1 (ICR) mice weighing 20 +/- 2 g were used in this study.
                    Experimental
                    Result(s)		 Melatonin and ghrelin showed synergistic effect on preventing cisplatin-induced ovarian damage via regulation of FOXO3a phosphorylation and binding to the p27 Kip1 promoter in primordial follicles.
References
Reference 1 Synergistic effect of melatonin and ghrelin in preventing cisplatin-induced ovarian damage via regulation of FOXO3a phosphorylation and binding to the p27 Kip1 promoter in primordial follicles. J Pineal Res. 2017 Oct;63(3).
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