Drug Combination Details
| General Information of the Combination (ID: C57775) | |||||
|---|---|---|---|---|---|
| Name | Neferine NP Info | + | Oxaliplatin Drug Info | ||
| Structure |
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+ |
|
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| Disease |
Hepatocellular carcinoma
[ICD-11: 2C12]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [2] | |||||
| Molecule(s)
Regulation |
Up-regulation | Expression | CDH1 | Molecule Info |
Pathway MAP
|
|
| Experimental
Result(s) |
Snail overexpression or TGF-Beta1-induced EMT attenuated Neferine-mediated OXA sensitization in HCC. | |||||
| Experiment 2 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | VIM | Molecule Info |
Pathway MAP
|
|
| Experimental
Result(s) |
Snail overexpression or TGF-Beta2-induced EMT attenuated Neferine-mediated OXA sensitization in HCC. | |||||
