Drug Combination Details

General Information of the Combination (ID: C58098)
Name Flavopiridol   NP Info  + Cisplatin   Drug Info 
Structure +
Disease
Malignant mesenchymal neoplasm [ICD-11: 2B5D]
Phase 2 [1]
Peritoneal cancer [ICD-11: 2C51]
Phase 2 [1]
Solid tumour/cancer [ICD-11: 2A00-2F9Z]
Phase 1 [2]
Lung cancer [ICD-11: 2C25]
Investigative [3]
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Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. Enhancing Drug Efficacy by This Combination
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Experiment 1 Reporting the Effect of This Combination [3]
                    In-vitro Model A-549 CVCL_0023 Lung adenocarcinoma Homo sapiens
                    Experimental
                    Result(s)		 Administration of flavopiridol for 24 h followed 3 days later by exposure to 5-fluorouracil resulted in a highly synergistic interaction.
References
Reference 1 ClinicalTrials.gov (NCT00083122) Cisplatin and Flavopiridol in Treating Patients With Advanced Ovarian Epithelial Cancer or Primary Peritoneal Cancer U.S. National Institutes of Health.
Reference 2 ClinicalTrials.gov (NCT00003690) Flavopiridol Plus Cisplatin or Carboplatin in Treating Patients With Advanced Solid Tumors U.S. National Institutes of Health.
Reference 3 Cytotoxic synergy between flavopiridol (NSC 649890, L86-8275) and various antineoplastic agents: the importance of sequence of administration. Cancer Res. 1997 Aug 15;57(16):3375-80.
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