Drug Combination Details

General Information of the Combination (ID: C59135)
Name Flavopiridol   NP Info  + Anti-CD25 monoclonal antibody   Drug Info 
Structure +
Disease
Anaplastic large cell lymphoma [ICD-11: 2A90]
Investigative [1]
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. Enhancing Drug Efficacy by This Combination
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Experiment 1 Reporting the Effect of This Combination [1]
                    In-vitro Model FCCH1043 CVCL_M518 Adult T acute lymphoblastic leukemia Homo sapiens
MT-2 CVCL_2631 Healthy Homo sapiens
HuT 102 CVCL_3526 Mycosis fungoides and Sezary syndrome Homo sapiens
                    In-vivo Model The xenograft model was established by intraperitoneal injection of 1.5*107 MET-1 cells into SCID/NOD mice.
                    Experimental
                    Result(s)		 Combination of the flavopiridol and anti-CD25 monoclonal antibody dramatically enhanced the antitumor effect.
References
Reference 1 Combination therapy for adult T-cell leukemia-xenografted mice: flavopiridol and anti-CD25 monoclonal antibody. Blood. 2005 Feb 1;105(3):1231-6.
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