Drug Combination Details
| General Information of the Combination (ID: C59759) | |||||
|---|---|---|---|---|---|
| Name | Cidofovir NP Info | + | Idoxuridine Drug Info | ||
| Structure |
|
+ |
|
||
| Disease |
Vaccinia
[ICD-11: 1E73]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| In-vitro Model | Chick embryo fibroblasts infected with Bratislava and RIIPD strains | Microorganism model | Gallus gallus | |||
| Experimental
Result(s) |
The combined effect of CDV and IUdR on VV replication in monolayer CEF cultures was characterized as a markedly synergistic one. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Synergistic combination effect of cidofovir and idoxuridine on vaccinia virus replication. Antivir Chem Chemother. 2006;17(2):53-8. | |||
